8월 12일 H2AX: functional roles and potential applications Liu Xiaoshan

H2AX: functional roles and potential applications Jennifer S. Dickey & Christophe E. Redon & Asako J. Nakamura & Brandon J. Baird & Olga A. Sedelnikova & William M. Bonner Abstract Upon DNA double-strand break (DSB) induction in mammals, the histone H2A variant, H2AX, becomes rapidly phosphorylated at serine 139. This modified form, termed γ-H2AX, is easily identified with antibodies and serves as a sensitive indicator of DNA DSB formation. This review focuses on the potential clinical applications of γ-H2AX detection in cancer and in response to other cellular stresses. In addition, the role of H2AX in homeostasis and disease will be discussed. Recent work indicates that γ-H2AX detection may become a powerful tool for monitoring genotoxic events associated with cancer development and tumor progression.