(2008.7-2009.6) Technical Development to Assess Environmental Pollution and Prevention, 환경오염 평가 및 예방을 위한 독성검정기술 개발 (2008-2010 과학재단 국제협력연구)

발주처명 : 과학재단

기간 : 2008.07.01 ~ 2009.06.30

 

Technical Development to Assess Environmental Pollution and Prevention (KOSEF, Joint Research Project under Korea-Japan Basic Scientific Cooperation Program 2008-2010) Unless Asian companies demonstrate the safety of their chemical products following methods required by REACH (Registration, Evaluation, and Authorization of Chemicals), they are not allowed to export the products to EC. To overcome this difficulty, we are going to set up a unified framework for simple and sensitive chemical hazard assessment techniques among Asian countries, and then require EC to import the industrial products from Asia. To this end, we must develop a standardized technique to identify toxic chemicals in very fast and sensitive manner. The aim of this proposed research is to establish a novel bioassay using gene modified medaka fishes that can be employed for prompt and reliable screening for hazard of chemicals. Several standardized laboratory animals need relatively high concentrations of chemicals or long exposure durations for identifying the toxic effect. To increase the sensitivity of the biological assays, we wish to use gene disrupted Medaka fishes. Dr. Takeda (Kyoto Univ.) firstly established a method of disrupting any given genes in the Medaka fishes. Dr. Koizumi (Kyoto Univ.) wishes to screen risk of chemicals together with Dr. Choi (Seoul National Univ.), who has evaluated chemical risk using the Medaka fishes. In this proposed collaboration, Dr Takeda will generate a few gene disrupted Medaka, and Dr Choi will evaluate the utility of the novel hazard assessment methods against several internationally accepted hazard assessment techniques.